Article
A human multi-lineage hepatic organoid model for liver fibrosis.
Nature communications - 22 Oct 2021
Guan Yuan, Enejder Annika, Wang Meiyue, Fang Zhuoqing, Cui Lu, Chen Shih-Yu, Wang Jingxiao, Tan Yalun, Wu Manhong, Chen Xinyu, Johansson Patrik K, Osman Issra, Kunimoto Koshi, Russo Pierre, Heilshorn Sarah C, Peltz Gary
Abstract excerpt
To investigate the pathogenesis of a congenital form of hepatic fibrosis, human hepatic organoids were engineered to express the most common causative mutation for Autosomal Recessive Polycystic Kidney Disease (ARPKD). Here we show that these hepatic organoids develop the key features of ARPKD liver pathology (abnormal bile ducts and fibrosis) in only 21 days. The ARPKD mutation increases collagen abundance and...
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