Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells.

doi:10.1016/j.stemcr.2015.02.021

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Article

Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells.

Stem cell reports - 12 May 2015

Wilson Andrew A, Ying Lei, Liesa Marc, Segeritz Charis-Patricia, Mills Jason A, Shen Steven S, Jean Jyhchang, Lonza Geordie C, Liberti Derek C, Lang Alex H, Nazaire Jean, Gower Adam C, Müeller Franz-Josef, Mehta Pankaj, Ordóñez Adriana, Lomas David A, Vallier Ludovic, Murphy George J, Mostoslavsky Gustavo, Spira Avrum, Shirihai Orian S, Ramirez Maria I, Gadue Paul, Kotton Darrell N

Abstract excerpt

Induced pluripotent stem cells (iPSCs) provide an inexhaustible source of cells for modeling disease and testing drugs. Here we develop a bioinformatic approach to detect differences between the genomic programs of iPSCs derived from diseased versus normal human cohorts as they emerge during in vitro directed differentiation. Using iPSCs generated from a cohort carrying mutations (PiZZ) in the gene responsible...

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Identifiers

PMID: 25843048
DOI: 10.1016/j.stemcr.2015.02.021
PMCID: PMC4437473

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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