Article

A new insight into MYC action: control of RNA polymerase II methylation and transcription termination

2022-02-17

Abstract excerpt

A common catastrophic event in most human cancers is deregulation of MYC, a multifunctional transcription factor that controls gene expression in partnership with MAX and drives key biological mechanisms of the cell. Restraining its activity impairs cancer cell features and prevents tumor development, as shown by Omomyc - a 90 amino acid mini-protein interfering with MYC activity. MYC regulates many aspects of tra...

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Literature Corpus work: cef7ccb0-2376-5e06-9f34-2358fca4ac4f
DOI: 10.1101/2022.02.17.480813

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