Article

Distribution and vulnerability of transcriptional outputs across the genome in Myc-amplified medulloblastoma cells

2021-06-07

Abstract excerpt

Myc plays a central role in tumorigenesis by orchestrating the expression of genes essential to numerous cellular processes 1-4 . While it is well established that Myc functions by binding to its target genes to regulate their transcription 5 , the distribution of the transcriptional output across the human genome in Myc-amplified cancer cells, and the susceptibility of such transcriptional outputs to therapeuti...

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Literature Corpus work: 16468e17-5b87-5210-bab4-5be56becfbc8
DOI: 10.1101/2021.06.07.447394

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