Article

Protein arginine methyltransferase 5 (PRMT5) is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer

2023-07-10

Abstract excerpt

<title>Abstract</title> <p>CDK4/6 inhibitors (CDK4/6i) have improved survival of patients with estrogen receptor-positive (ER+) breast cancer. However, patients treated with CDK4/6i eventually develop drug resistance and progress. <italic>RB1 </italic>loss-of-function alterations confer acquired resistance to CDK4/6i, but the optimal therapy for these patients is unclear. Using a genome-wide CRISPR screen, we ide...

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Literature Corpus work: 54f42b32-a0e0-5c28-a12c-cb52f1dc4100
DOI: 10.21203/rs.3.rs-2966905/v1

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