Article

Arginine citrullination at the C-terminal domain controls RNA polymerase II transcription

2017-11-08

Abstract excerpt

<h4>Highlights</h4> Peptidyl arginine deiminase 2 (PADI2) citrullinates arginine1810 (cit1810) present at carboxy-terminal domain of RNA polymerase II (RNAP2-CTD). PADI2 and R1810 of RNAP2-CTD regulate transcription and proliferation of breast cancer cells. Absence of cit1810 at RNAP2-CTD leads to RNAP2 accumulation at proximal promoter regions. Cit1810 at RNAP2-CTD facilitate interaction with P-TFEb complex. <h4...

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Literature Corpus work: b6e23708-d575-514a-8f49-8afe9a838db2
DOI: 10.1101/216143

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