Back to search

Article

The novel RNA polymerase I transcription inhibitor PMR-116 exploits a critical therapeutic vulnerability in a broad-spectrum of high <i>MYC</i> malignancies

2025-04-21

Abstract excerpt

Ribosome biogenesis (RiBi) is a key determinant of cell growth and proliferation and is highly elevated in cancer due to the activation by oncogenes such as MYC . First-generation RiBi inhibitor CX-5461, while demonstrating clinical potential for cancer treatment, also induces DNA damage through off-target inhibition of TOP2⍺ and potentially other mechanisms, bringing into question RiBi as a target for cancer the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
54213fc3-f193-5d0d-a589-1ce1839abaa3
DOI
10.1101/2025.04.19.649466
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The novel RNA polymerase I transcription inhibitor PMR-116 exploits a critical therapeutic vulnerability in a broad-spectrum of high <i>MYC</i> malignanciesDOI 10.1101/2025.04.19.649466
Novel RNA Polymerase I and Cyclin Dependent Kinase combination therapy for the treatment of aggressive Acute Myeloid LeukemiaSemantic proximity
RNA Polymerase I Inhibition with CX-5461 as a Novel Therapeutic Strategy to Target MYC in Multiple Myeloma.Semantic proximity
CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancerSemantic proximity
Inhibition of RNA Polymerase I Transcription Activates Targeted DNA Damage Response and Enhances the Efficacy of PARP Inhibitors in High-Grade Serous Ovarian CancerSemantic proximity
Loss of <i>UBP1</i> drives oxaliplatin resistance through a targetable dependency on translation initiationSemantic proximity
Therapeutic Targeting of the General RNA Polymerase II Transcription MachinerySemantic proximity
BRD9 inhibition induces selective radiosensitivity in glioblastoma through MYC pathway modulationSemantic proximity
Targeting replication stress in neuroblastoma by exploiting the synergistic potential of second generation RRM2 and CHK1 inhibitorsSemantic proximity
Targeting the ribosome to treat multiple myelomaSemantic proximity
PI3K/mTOR activity sensitizes cancer cells to nucleolar stressSemantic proximity
Dysregulated Ribosome Biogenesis Reveals Therapeutic Liabilities in Cancer.Semantic proximity
Synthetic lethality by targeting the RUVBL1/2-TTT complex in mTORC1-hyperactive cancer cellsSemantic proximity
Select a neighboring publication to make it the new centre.