Mouse models of pediatric high-grade gliomas with MYCN amplification reveal intratumoral heterogeneity and lineage signatures.

doi:10.1038/s41467-023-43564-w

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Article

Mouse models of pediatric high-grade gliomas with MYCN amplification reveal intratumoral heterogeneity and lineage signatures.

Nature communications - 24 Nov 2023

Schoof Melanie, Godbole Shweta, Albert Thomas K, Dottermusch Matthias, Walter Carolin, Ballast Annika, Qin Nan, Olivera Marlena Baca, Göbel Carolin, Neyazi Sina, Holdhof Dörthe, Kresbach Catena, Peter Levke-Sophie, Epplen Gefion Dorothea, Thaden Vanessa, Spohn Michael, Blattner-Johnson Mirjam, Modemann Franziska, Mynarek Martin, Rutkowski Stefan, Sill Martin, Varghese Julian, Afflerbach Ann-Kristin, Eckhardt Alicia, Münter Daniel, Verma Archana, Struve Nina, Jones David T W, Remke Marc, Neumann Julia E, Kerl Kornelius, Schüller Ulrich

Abstract excerpt

Pediatric high-grade gliomas of the subclass MYCN (HGG-MYCN) are highly aggressive tumors frequently carrying MYCN amplifications, TP53 mutations, or both alterations. Due to their rarity, such tumors have only recently been identified as a distinct entity, and biological as well as clinical characteristics have not been addressed specifically. To gain insights into tumorigenesis and molecular profiles of these...

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PMID: 38001143
DOI: 10.1038/s41467-023-43564-w
PMCID: PMC10673884

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