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Article

Optimizing preclinical pediatric low-grade glioma models for meaningful clinical translation.

Neuro-oncology - 2 Nov 2023

Milde Till, Fangusaro Jason, Fisher Michael J, Hawkins Cynthia, Rodriguez Fausto J, Tabori Uri, Witt Olaf, Zhu Yuan, Gutmann David H

Abstract excerpt

Pediatric low-grade gliomas (pLGGs) are the most common brain tumor in young children. While they are typically associated with good overall survival, children with these central nervous system tumors often experience chronic tumor- and therapy-related morbidities. Moreover, individuals with unresectable tumors frequently have multiple recurrences and persistent neurological symptoms. Deep molecular analyses of...

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Identifiers

PMID: 37738646
DOI: 10.1093/neuonc/noad125
PMCID: PMC10628935

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