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Current Landscape of Preclinical Models for Pediatric Gliomas: Clinical Implications and Future Directions

2 Jul 2025

Abstract excerpt

Pediatric high-grade gliomas (pHGGs), particularly diffuse midline gliomas (DMGs), are among the most lethal brain tumors due to poor survival and resistance to therapies. DMGs possess a distinct genetic profile, primarily driven by hallmark mutations such as H3K27M, ACVR1, and PDGFRA mutations/amplifications and TP53 inactivation, all of which contribute to tumor biology and therapeutic resistance. Developing...

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PMID: 40647519
DOI: 10.3390/cancers17132221

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