Article
Genetic driver mutations introduced in identical cell-of-origin in murine glioblastoma reveal distinct immune landscapes but similar response to checkpoint blockade.
Glia - 1 Oct 2020
Chen Zhihong, Herting Cameron J, Ross James L, Gabanic Ben, Puigdelloses Vallcorba Montse, Szulzewsky Frank, Wojciechowicz Megan L, Cimino Patrick J, Ezhilarasan Ravesanker, Sulman Erik P, Ying Mingyao, Ma'ayan Avi, Read Renee D, Hambardzumyan Dolores
Abstract excerpt
Glioblastoma (GBM) is the most aggressive primary brain tumor. In addition to being genetically heterogeneous, GBMs are also immunologically heterogeneous. However, whether the differences in immune microenvironment are driven by genetic driver mutation is unexplored. By leveraging the versatile RCAS/tv-a somatic gene transfer system, we establish a mouse model for Classical GBM by introducing EGFRvIII expression...
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