Article

Functional and topological analysis of PSENEN, the fourth subunit of the γ-secretase complex

2023-07-28

Abstract excerpt

The γ-secretase complexes are intramembrane cleaving proteases involved in the generation of the Aβ peptides in Alzheimer’s Disease. The complex consists of four subunits, with Presenilin, harboring the catalytic site. Here, we study the role of the smallest subunit, PSENEN or Presenilin enhancer 2 (PEN-2), encoded by the gene Psenen , in vivo and in vitro . We find a profound Notch-deficiency phenotype in Pse...

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Literature Corpus work: d5335441-bf9c-5093-be5b-1fecd3c4ca4b
DOI: 10.1101/2023.07.28.550932

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