Article
Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates.
The Journal of biological chemistry - 3 Dec 2010
Gong Ping, Vetrivel Kulandaivelu S, Nguyen Phuong D, Meckler Xavier, Cheng Haipeng, Kounnas Maria Z, Wagner Steven L, Parent Angèle T, Thinakaran Gopal
Abstract excerpt
The γ-secretase protein complex executes the intramembrane proteolysis of amyloid precursor protein (APP), which releases Alzheimer disease β-amyloid peptide. In addition to APP, γ-secretase also cleaves several other type I membrane protein substrates including Notch1 and N-cadherin. γ-Secretase is made of four integral transmembrane protein subunits: presenilin (PS), nicastrin, APH1, and PEN2. Multiple lines of...
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