Article

Maladaptive myelination promotes epileptogenesis in absence epilepsy

2020-08-21

Abstract excerpt

<h4>Summary</h4> Neuronal activity can influence the generation of new oligodendrocytes (oligodendrogenesis) and myelination. In health, this is an adaptive process that can increase synchrony within distributed neuronal networks and contribute to cognitive function. We hypothesized that in seizure disorders, aberrant neuronal activity may promote maladaptive myelination that contributes to pathogenesis. Absence...

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Literature Corpus work: cef245c8-44ef-5c32-87ef-7aa0ab4e586e
DOI: 10.1101/2020.08.20.260083

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