Article

BMAL1 loss in oligodendroglial lineage cells dysregulates myelination and sleep

2022-04-30

Abstract excerpt

Myelination depends on maintenance of oligodendrocytes that arise from oligodendrocyte precursor cells (OPCs). We show that the dynamic nature of oligodendroglia and myelination are regulated by the circadian transcription factor BMAL1. Bmal1 knockdown in OPCs during development – but not adulthood – decreases OPC proliferation, whereas BMAL1 regulates OPC morphology throughout life. OPC-specific Bmal1 deficienc...

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Literature Corpus work: e424c958-403a-5974-9caf-0260cf9289fe
DOI: 10.1101/2022.04.28.489946

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