Article

Slc35a2 mosaic knockout impacts cortical development, dendritic arborisation, and neuronal firing in the developing brain

2024-02-18

Abstract excerpt

<h4>Objective: </h4> Mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) is an important cause of drug-resistant epilepsy. A significant subset of individuals diagnosed with MOGHE display somatic mosaicism for loss-of-function variants in SLC35A2, which encodes the UDP-galactose transporter. We developed a mouse model to investigate the mechanism by which disruption of t...

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Literature Corpus work: cc23ef0e-76f4-5011-ab1f-71d76403d265
DOI: 10.1101/2024.02.18.580216

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