Article

Cerebral Organoids Uncover Mechanisms of Neural Activity Changes in Epileptogenesis

2025-08-26

Abstract excerpt

Neurological disorders often originate from progressive brain network dysfunctions that start years before symptoms appear. How these changes emerge in the developing human brain remains elusive due to a lack of tractable model systems. Here, we show a cerebral organoid model of Tuberous Sclerosis Complex (TSC) that recapitulates hallmarks of epileptogenesis in vitro. We compare extracellular recordings of TSC org...

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Literature Corpus work: e43dbcf0-31e5-5f92-8160-c5c01c55681a
DOI: 10.1101/2025.08.26.672285

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