Article

Absence seizures and sleep-wake abnormalities in a rat model of <i>GRIN2B</i> neurodevelopmental disorder

2024-02-28

Abstract excerpt

Pathogenic mutations in GRIN2B are an important cause of severe neurodevelopmental disorders resulting in epilepsy, autism and intellectual disability. GRIN2B encodes the GluN2B subunit of N-methyl-D-aspartate receptors (NMDARs), which are ionotropic glutamate receptors critical for normal development of the nervous system and synaptic plasticity. Here, we characterized a novel Grin2b heterozygous knockout rat...

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Literature Corpus work: ca22385c-cd04-5edc-987c-9c289b7383ba
DOI: 10.1101/2024.02.27.582289

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