Article

Distinct and shared synergistic effects of high-fat and high-iron diets on liver tumorigenesis and transcriptomic remodeling in mice

2026-05-27

Abstract excerpt

<h4>Background and Aims</h4> The incidence of hepatocellular carcinoma (HCC) is increasingly driven by metabolic risk factors, including obesity and iron overload. Although high-fat and high-iron diets independently promote hepatocarcinogenesis, their shared and distinct molecular effects remain unclear. We sought to define how dietary fat and iron differentially shape HCC development. <h4>Approach</h4> Male C3H...

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Literature Corpus work: cecc4390-e41e-54b0-934f-08b7f0b8a761
DOI: 10.64898/2026.05.24.727480

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