Back to search

Article

Integrated multi-omics reveals adaptive anti-oxidant remodeling in early alcohol-associated liver disease

2026-06-01

Abstract excerpt

Alcohol-associated liver disease (ALD) is a leading cause of liver-related morbidity and mortality. Although various omics approaches have revealed early metabolic alterations, individual datasets provide limited mechanistic insight. Here, we integrated RNA sequencing with mass spectrometry–based analyses to quantify gene expression, protein abundance, proteome and acetylome dynamics, and metabolic fluxes in liver...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
0156174e-b041-520e-b0af-862b374cd05c
DOI
10.64898/2026.05.28.728507
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Integrated multi-omics reveals adaptive anti-oxidant remodeling in early alcohol-associated liver diseaseDOI 10.64898/2026.05.28.728507
Spatio-Temporal Multiscale Analysis of Western Diet-Fed Mice Reveals a Translationally Relevant Sequence of Events during NAFLD ProgressionSemantic proximity
Chronic metabolic stress drives developmental programs and loss of tissue functions in non-transformed liver that mirror tumor states and stratify survivalSemantic proximity
Alcohol and the mechanisms of liver diseaseSemantic proximity
Chronic alcohol intake elicits distinct multi-omic profiles in the liver <i>versus</i> skeletal muscle of miceSemantic proximity
Gradual DNA methylation changes reveal transcription factors implicated in metabolic dysfunction-associated steatotic liver disease progression and epigenetic age accelerationSemantic proximity
Global molecular landscape of early MASLD progression in obesitySemantic proximity
Alcohol-related liver disease disrupts bile acid synthesis and is associated with compensatory gut microbiota changesSemantic proximity
A paired liver biopsy and plasma proteomics study reveals circulating biomarkers for alcohol-related liver diseaseSemantic proximity
Molecular Insights into Alcohol-Induced Hepatocarcinogenesis and Comorbidities: Unravelling the Clinical Markers SymphonySemantic proximity
Early-Life Environmental Exposures Reprogram Epigenomic Aging to Alter Gene Expression TrajectoriesSemantic proximity
Comprehensive meta-analysis reveals distinct gene expression signatures of MASLD progressionSemantic proximity
Epigenetic modification in alcohol‐related liver diseasesSemantic proximity
Select a neighboring publication to make it the new centre.