Article

Role of Long Chain Acyl-CoA Synthetases in MASH-driven Hepatocellular Carcinoma and Ferroptosis

2025-03-15

Abstract excerpt

<h4>ABSTRACT</h4> Metabolic-associated steatohepatitis-driven hepatocellular carcinoma (MASH-HCC) incidence is rapidly rising worldwide. Lipid metabolic reprogramming is a hallmark of solid tumors to satisfy cancer high metabolic demand. However, it may confer sensitivity to ferroptosis, a cell death mode driven by iron-dependent lipid peroxidation. In this report, we describe the lipid metabolic landscape in MAS...

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Literature Corpus work: c674d6fd-3dba-5e4f-a804-723169b77ff0
DOI: 10.1101/2025.03.13.642692

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