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METTL3-Driven m6A Modification of Cpt1a Gene in High Fat Diet Related Liver Cancer Tumor Macrophages Facilitates Type II Macrophage Differentiation

26 May 2025

Abstract excerpt

Objective: Obesity induces chronic inflammation and hormonal imbalances that contribute to tumor growth. This study explores the less understood dynamics of tumor-related macrophages under a high-fat diet and its consequent impact on tumor growth, with a focus on elucidating the role of high-fat diets on macrophage behavior in liver cancer. Methods: We established a mouse obesity model using a high-fat diet,...

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PMID: 40464511
DOI: 10.31083/fbl36971

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