Article

Single-cell RNA transcriptome analysis reveals CXCL16/CXCR6 as maintenance factors for CNS tissue resident T cells that drive synapse elimination during viral recovery

2021-10-08

Abstract excerpt

<h4>Background</h4> Emerging RNA viruses that target the central nervous system (CNS) lead to cognitive sequelae in survivors. Studies in humans and mice infected with West Nile virus (WNV), a re-emerging RNA virus associated with learning and memory deficits, revealed microglial-mediated synapse elimination within the hippocampus. Moreover, CNS resident memory T (T R M) cells activate microglia, limiting synaps...

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Literature Corpus work: cec8107e-135a-58a5-9e58-e7958cb5ddc2
DOI: 10.1101/2021.10.08.463715

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