Article

A eutherian-specific metaviral gene, <i>RTL6</i> , coordinates microglial inflammatory responsiveness and state regulation

2026-07-16

Abstract excerpt

RTL6 (also known as SIRH3 ) is a eutherian-specific metavirus-derived gene highly conserved among placental mammals. We previously demonstrated that RTL6 is expressed in microglia and secreted into the brain extracellular space, where it mediates the trapping and clearance of bacterial lipopolysaccharide (LPS). However, its role in microglial TLR4 signaling remained unclear. To investigate the earliest LPS respon...

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Literature Corpus work: 1604315f-a556-5899-85d5-b0fecaba5286
DOI: 10.64898/2026.07.15.738833

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