Article

High expression of CD38 and MHC class II on CD8 + T cells during severe influenza disease reflects bystander activation and trogocytosis

2021-02-09

Abstract excerpt

Although co-expression of CD38 and HLA-DR on CD8 + T cells reflects activation during influenza, SARS-CoV-2, Dengue, Ebola and HIV-1 viral infections, high and prolonged CD38 + HLA-DR + expression can be associated with severe and fatal disease outcomes. As the expression of CD38 + HLA-DR + is poorly understood, we used mouse models of influenza A/H7N9, A/H3N2 and A/H1N1 infection to investigate the mechanism...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cec7987d-4d4c-5276-9401-5a3ddfd8e562
DOI: 10.1101/2021.02.09.430410

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High expression of CD38 and MHC class II on CD8 + T cells during severe influenza disease reflects bystander activation and trogocytosisDOI 10.1101/2021.02.09.430410Read

High expression of CD38 and MHC class II on CD8 + T cells during severe influenza disease reflects bystander activation and trogocytosisSemantic proximity Read

Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 diseaseSemantic proximity Read

Potential killers exposed: tracking endogenous influenza-specific CD8+ T cells.Semantic proximity Read

Perturbed CD8+ T cell immunity across universal influenza epitopes in the elderlySemantic proximity Read

Self-reactive memory-phenotype CD8 T cells exhibit both MHC-restricted and non-MHC-restricted cytotoxicity: a role for the T-cell receptor and natural killer cell receptors.Semantic proximity Read

HLA-B*27:05 alters immunodominance hierarchy of universal influenza-specific CD8+ T cellsSemantic proximity Read

Large-Scale HLA Tetramer Tracking of T Cells during Dengue Infection Reveals Broad Acute Activation and Differentiation into Two Memory Cell FatesSemantic proximity Read

CD8+T-cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorphSemantic proximity Read

CD8+ T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph.Semantic proximity Read

Kinetics and Phenotype of the CD4 T Cell Response to Influenza Virus InfectionsSemantic proximity Read

Characterization of CD8+ T cell repertoire diversity and persistence in the influenza A virus model of localized, transient infection.Semantic proximity Read

Protective capacity and epitope specificity of CD8+ T cells responding to lethal West Nile virus infectionSemantic proximity Read

High expression of CD38 and MHC class II on CD8 <sup>+</sup> T cells during severe influenza disease reflects bystander activation and trogocytosis

Abstract excerpt

Topics

Identifiers and source

Related research