Article
CD8+ T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph.
Nature communications - 18 May 2021
Hensen Luca, Illing Patricia T, Bridie Clemens E, Nguyen Thi H O, Koutsakos Marios, van de Sandt Carolien E, Mifsud Nicole A, Nguyen Andrea T, Szeto Christopher, Chua Brendon Y, Halim Hanim, Rizzetto Simone, Luciani Fabio, Loh Liyen, Grant Emma J, Saunders Phillipa M, Brooks Andrew G, Rockman Steve, Kotsimbos Tom C, Cheng Allen C, Richards Michael, Westall Glen P, Wakim Linda M, Loudovaris Thomas, Mannering Stuart I, Elliott Michael, Tangye Stuart G, Jackson David C, Flanagan Katie L, Rossjohn Jamie, Gras Stephanie, Davies Jane, Miller Adrian, Tong Steven Y C, Purcell Anthony W, Kedzierska Katherine
Abstract excerpt
Indigenous people worldwide are at high risk of developing severe influenza disease. HLA-A*24:02 allele, highly prevalent in Indigenous populations, is associated with influenza-induced mortality, although the basis for this association is unclear. Here, we define CD8+ T-cell immune landscapes against influenza A (IAV) and B (IBV) viruses in HLA-A*24:02-expressing Indigenous and non-Indigenous individuals, human...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.