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Article

Perturbed CD8+ T cell immunity across universal influenza epitopes in the elderly

20 Sept 2017

Abstract excerpt

Abstract Influenza epidemics lead to severe illness, life-threatening complications, and deaths, especially in the elderly. As CD8+ T cells are associated with rapid recovery from influenza, we investigated the effects of aging on antigen-specific CD8+ T cells across the universal influenza epitopes in humans. We show that aging is characterized by altered frequencies in T cell subsets, with naive T cells being...

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PMID: 28928269
DOI: 10.1189/jlb.5ma0517-207r

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