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Article

Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease

20 Feb 2018

Abstract excerpt

Abstract Severe influenza A virus (IAV) infection is associated with immune dysfunction. Here, we show circulating CD8+ T-cell profiles from patients hospitalized with avian H7N9, seasonal IAV, and influenza vaccinees. Patient survival reflects an early, transient prevalence of highly activated CD38+HLA-DR+PD-1+ CD8+ T cells, whereas the prolonged persistence of this set is found in ultimately fatal cases....

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PMID: 29483513
DOI: 10.1038/s41467-018-03243-7

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