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Article

High expression of CD38 and MHC class II on CD8 + T cells during severe influenza disease reflects bystander activation and trogocytosis

1 Jan 2021

Abstract excerpt

Abstract Objectives Although co‐expression of CD38 and HLA‐DR reflects T‐cell activation during viral infections, high and prolonged CD38 + HLA‐DR + expression is associated with severe disease. To date, the mechanism underpinning expression of CD38 + HLA‐DR + is poorly understood. Methods We used mouse models of influenza A/H9N2, A/H7N9 and A/H3N2 infection to investigate mechanisms underpinning CD38 + MHC‐II +...

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PMID: 34522380
DOI: 10.1002/cti2.1336

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