Article

Activation of goblet cell stress sensor IRE1β is controlled by the mucin chaperone AGR2

2023-07-07

Abstract excerpt

As secretory cells specialized in the production of mucins, intestinal goblet cells are challenged by the need for efficient protein folding. Goblet cells express Inositol-Requiring Enzyme 1β (IRE1β), a unique unfolded protein response (UPR) sensor that is part of an adaptive mechanism that regulates the demands of mucin production and secretion. However, how IRE1β activity is tuned to mucus folding load remains u...

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Literature Corpus work: ceb3c0fd-6c26-5620-9272-ae1c397f5b5e
DOI: 10.1101/2023.07.06.547951

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