Article

Unveiling novel signaling roles for human KDELR3 and KDELR1

2025-03-20

Abstract excerpt

<h4>ABSTRACT</h4> KDEL receptors (KDELRs) prevent the secretion of soluble chaperones and enzymes meant to reside in the endoplasmic reticulum. While a single KDELR exists in yeast (ERD2), three variants are present in mammals, displaying high sequence similarity (73-83%). However, the phylogenetic conservation of the differences and the diverse tissue distribution of the three KDELRs suggest functional specializ...

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Literature Corpus work: a6522e5a-296c-5c2b-944f-5c981a8b3efa
DOI: 10.1101/2025.03.17.643648

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