Article

Distinct signalling roles of human KDELR3 and KDELR1

2025-10-09

Abstract excerpt

<title>Abstract</title> <p>KDEL receptors (KDELRs) prevent the secretion of soluble chaperones and enzymes meant to reside in the endoplasmic reticulum. While a single KDELR exists in yeast (ERD2), three variants are present in mammals, displaying high sequence similarity. All three can prevent the secretion of KDEL-bearing clients. However, their diverse tissue distribution and the extremely high phylogenetic co...

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Literature Corpus work: 3305f58d-0f33-562d-8ef3-6f6e96047ad1
DOI: 10.21203/rs.3.rs-7701947/v1

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