Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Agr2-associated ER stress promotes adherent-invasive E. coli dysbiosis and triggers CD103+ dendritic cell IL-23-dependent ileocolitis

1 Nov 2022

Abstract excerpt

Endoplasmic reticulum (ER) stress is associated with Crohn's disease (CD), but its impact on host-microbe interaction in disease pathogenesis is not well defined. Functional deficiency in the protein disulfide isomerase anterior gradient 2 (AGR2) has been linked with CD and leads to epithelial cell ER stress and ileocolitis in mice and humans. Here, we show that ileal expression of AGR2 correlates with mucosal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Eosinophilic Esophagitis
Share to Infant Nutrition and Health
Share to Inflammatory Bowel Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36384110
DOI: 10.1016/j.celrep.2022.111637

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Agr2-associated ER stress promotes adherent-invasive E. coli dysbiosis and triggers CD103+ dendritic cell IL-23-dependent ileocolitisPMID 36384110Read ↗

The unfolded protein response and gastrointestinal disease.Semantic proximity Read ↗

Endoplasmic reticulum stress and inflammation.Semantic proximity Read ↗

Human AGR2 Deficiency Causes Mucus Barrier Dysfunction and Infantile Inflammatory Bowel Disease.Semantic proximity Read ↗

The protein disulfide isomerase AGR2 is essential for production of intestinal mucus.Semantic proximity Read ↗

Endoplasmic reticulum stress: implications for inflammatory bowel disease pathogenesis.Semantic proximity Read ↗

The endoplasmic reticulum stress response chaperone Gp96, a host receptor for Crohn disease-associated adherent-invasive<i>Escherichia coli</i>Semantic proximity Read ↗

Autophagy, Microbial Sensing, Endoplasmic Reticulum Stress, and Epithelial Function in Inflammatory Bowel DiseaseSemantic proximity Read ↗

Activation of goblet cell stress sensor IRE1β is controlled by the mucin chaperone AGR2Semantic proximity Read ↗

Activation of goblet-cell stress sensor IRE1β is controlled by the mucin chaperone AGR2Semantic proximity Read ↗

Antimicrobial overproduction sustains intestinal inflammation by inhibiting <i>Enterococcus</i> colonizationSemantic proximity Read ↗

Transcriptomic signatures of host immune responses in aphthous ulcers, the earliest lesions of Crohn’s disease, suggest that a bacterial invasive challenge, rather than global dysbiosis, is the initiating factorSemantic proximity Read ↗

The epithelial-specific ER stress sensor ERN2/IRE1β enables host-microbiota crosstalk to affect colon goblet cell developmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.