Article
Human AGR2 Deficiency Causes Mucus Barrier Dysfunction and Infantile Inflammatory Bowel Disease.
Cellular and molecular gastroenterology and hepatology - 1 Jan 2021
Al-Shaibi Ahmad A, Abdel-Motal Ussama M, Hubrack Satanay Z, Bullock Alex N, Al-Marri Amna A, Agrebi Nourhen, Al-Subaiey Abdulrahman A, Ibrahim Nazira A, Charles Adrian K, Elawad Mamoun, Uhlig Holm H, Lo Bernice
Abstract excerpt
BACKGROUND & AIMS: The gastrointestinal epithelium plays a crucial role in maintaining homeostasis with the gut microbiome. Mucins are essential for intestinal barrier function and serve as a scaffold for antimicrobial factors. Mucin 2 (MUC2) is the major intestinal gel-forming mucin produced predominantly by goblet cells. Goblet cells express anterior gradient 2 (AGR2), a protein disulfide isomerase that is...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.