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Article

The protein disulfide isomerase AGR2 is essential for production of intestinal mucus.

Proceedings of the National Academy of Sciences of the United States of America - 28 Apr 2009

Park Sung-Woo, Zhen Guohua, Verhaeghe Catherine, Nakagami Yasuhiro, Nguyenvu Louis T, Barczak Andrea J, Killeen Nigel, Erle David J

Abstract excerpt

Protein disulfide isomerases (PDIs) aid protein folding and assembly by catalyzing formation and shuffling of cysteine disulfide bonds in the endoplasmic reticulum (ER). Many members of the PDI family are expressed in mammals, but the roles of specific PDIs in vivo are poorly understood. A recent homology-based search for additional PDI family members identified anterior gradient homolog 2 (AGR2), a protein...

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Source

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Identifiers

PMID: 19359471
DOI: 10.1073/pnas.0808722106
PMCID: PMC2678445

Genes

AGR2
MUC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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