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Article

Endoplasmic reticulum stress and inflammation.

Digestive diseases (Basel, Switzerland) - 1 Jan 2012

Adolph Timon-Eric, Niederreiter Lukas, Blumberg Richard S, Kaser Arthur

Abstract excerpt

Endoplasmic reticulum (ER) stress due to the presence of misfolded or unfolded proteins in the ER invokes a fundamental biological response, termed the unfolded protein response (UPR). The UPR is orchestrated by three main proximal effectors, of which the IRE1/XBP1 pathway represents the evolutionarily most conserved one. Due to its high secretory burden, the intestinal epithelium is highly susceptible to...

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Source

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Identifiers

PMID: 22796794
DOI: 10.1159/000338121
PMCID: PMC3423328

Genes

XBP1
AGR2
ORMDL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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