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Article

The unfolded protein response and gastrointestinal disease.

Seminars in immunopathology - 1 May 2013

Kaser Arthur, Adolph Timon Erik, Blumberg Richard S

Abstract excerpt

As the inner lining of the gastrointestinal tract, the intestinal epithelium serves an essential role in innate immune function at the interface between the host and microbiota. Given the unique environmental challenges and thus physiologic secretory functions of this surface, it is exquisitely sensitive to perturbations that affect its capacity to resolve endoplasmic reticulum (ER) stress. Genetic deletion of...

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Identifiers

PMID: 23588234
DOI: 10.1007/s00281-013-0377-5
PMCID: PMC3661271

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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