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Article

Why loss of Y? A pan-cancer genome analysis of tumors with loss of Y chromosome

1 Jan 2023

Abstract excerpt

Loss of the Y chromosome (LoY) is frequently observed in somatic cells of elderly men. However, LoY is highly increased in tumor tissue and correlates with an overall worse prognosis. The underlying causes and downstream effects of LoY are widely unknown. Therefore, we analyzed genomic and transcriptomic data of 13 cancer types (2375 patients) and classified tumors of male patients according to loss or retain of...

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Identifiers

PMID: 36874157
DOI: 10.1016/j.csbj.2023.02.024

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