Article

Selective loss of Y chromosomes in lung adenocarcinoma modulates the tumor immune environment through cancer/testis antigens

2024-09-22

Abstract excerpt

There is increasing recognition that the allosomes, X and Y, play an important role in health and disease beyond the determination of biological sex. A loss of the Y chromosome (LOY) occurs in most solid tumors in males and is often associated with worse survival, suggesting that LOY may give tumor cells a growth or survival advantage. We here use an expression-based continuous measure of LOY that allows us to inv...

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Literature Corpus work: ba1e2616-194b-58ef-900d-f34d59d5bdb2
DOI: 10.1101/2024.09.19.613876

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