Article

The wake- and sleep-modulating neurons of the lateral hypothalamic area demonstrate a differential pattern of degeneration in Alzheimer’s disease

2024-03-12

Abstract excerpt

<h4>Background</h4> Sleep-wake dysfunction is an early and common event in Alzheimer’s disease (AD). The lateral hypothalamic area (LHA) regulates the sleep and wake cycle through wake-promoting orexinergic neurons (Orx N ) and sleep-promoting melanin-concentrating hormone or MCHergic neurons (MCH N ). These neurons share close anatomical proximity with functional reciprocity. This study investigated LHA Orx N...

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Literature Corpus work: ce7e2b2e-6cc3-5060-b736-626f164dacd6
DOI: 10.1101/2024.03.06.583765

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