Article

Lateral hypothalamus drives early-onset sleep alterations in amyotrophic lateral sclerosis

2024-08-21

Abstract excerpt

Lateral hypothalamic neurons producing melanin-concentrating hormone (MCH) and orexin/hypocretin are involved in sleep regulation. Both MCH and orexin neurons are altered in amyotrophic lateral sclerosis (ALS), the most common adult-onset motor neuron disease. However, sleep alterations are currently poorly characterized in ALS, and could represent either early symptoms or late consequences of disease progression....

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Literature Corpus work: c6a515e3-11af-56e0-9cbf-5fe157a738c0
DOI: 10.1101/2024.08.21.24312343

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