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Melanin Concentrating Hormone- and sleep-dependent synaptic downscaling is impaired in Alzheimer’s Disease

2021-05-21

Abstract excerpt

In Alzheimer’s disease (AD), pathophysiological changes in the hippocampus cause deficits in episodic memory formation, leading to cognitive impairment 1,2 . Neuronal hyperactivity is observed early in AD 3,4 . Here, we find that homeostatic mechanisms transiently counteract increased neuronal activity in the hippocampal CA1 region of the App NL-G-F humanized knock-in mouse model for AD 5 , but ultimately fail...

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Literature Corpus work
299cadf4-9470-5e60-b3de-d0c379e19a1c
DOI
10.1101/2021.05.21.445007
Open publication

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Melanin Concentrating Hormone- and sleep-dependent synaptic downscaling is impaired in Alzheimer’s DiseaseDOI 10.1101/2021.05.21.445007
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