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Deep transcriptome profiling of human hypothalamic agouti-related protein and proopiomelanocortin neurons regulating energy homeostasis

2025-08-19

Abstract excerpt

<h4>Summary</h4> We have developed and validated a pioneering ‘IHC/LCM-Seq’ method for transcriptome profiling of spatially defined neuronal cell types detected with immunohistochemistry in sections of formaldehyde-fixed human brains. IHC/LCM-Seq provided unprecedented insight, with 14,000-16,000 transcripts identified, into the gene expression landscape of human agouti-related peptide (AgRP) neurons, which drive...

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Literature Corpus work
e769f4e4-14c0-5911-86a7-5de747479c48
DOI
10.1101/2025.08.19.671088
Open publication

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Deep transcriptome profiling of human hypothalamic agouti-related protein and proopiomelanocortin neurons regulating energy homeostasisDOI 10.1101/2025.08.19.671088
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