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Article

Neurodegenerative disorders and gut-brain interactions.

The Journal of clinical investigation - 1 Jul 2021

Singh Alpana, Dawson Ted M, Kulkarni Subhash

Abstract excerpt

Neurodegenerative disorders (NDs) affect essential functions not only in the CNS, but also cause persistent gut dysfunctions, suggesting that they have an impact on both CNS and gut-innervating neurons. Although the CNS biology of NDs continues to be well studied, how gut-innervating neurons, including those that connect the gut to the brain, are affected by or involved in the etiology of these debilitating and...

Topics

Alzheimer Disease
Amyotrophic Lateral Sclerosis
Animals
Brain
Digestive System
Disease Models, Animal
Disease Progression
Dysbiosis
Enteric Nervous System
Gastrointestinal Microbiome
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Huntington Disease

Models, Neurological

Mutation

Neurodegenerative Diseases

Parkinson Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 34196307
DOI: 10.1172/JCI143775
PMCID: PMC8245172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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