Article

Multifaceted impact of specialized neuropeptide-intensive neurons on the selective vulnerability in Alzheimer’s disease

2023-11-16

Abstract excerpt

<h4>INTRODUCTION</h4> Widespread disruption of neuropeptide (NP) networks in Alzheimer’s disease (AD) and disproportionate absence of neurons expressing h igh N P- p roducing, coined as HNP neurons, have been reported for the entorhinal cortex (EC) of AD brains. Hypothesizing that functional features of HNP neurons are involved in the early pathogenesis of AD, we aim to understand the molecular mechanisms unde...

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Literature Corpus work: 276c1da9-a2fc-5a79-a7f4-c83d7e3f803a
DOI: 10.1101/2023.11.13.566905

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