Article

SPINT2 inhibits proteases involved in activation of both influenza viruses and metapneumoviruses

2019-08-31

Abstract excerpt

Viruses possessing class I fusion proteins require proteolytic activation by host cell proteases to mediate fusion with the host cell membrane. The mammalian SPINT2 gene encodes a protease inhibitor that targets trypsin-like serine proteases. Here we show the protease inhibitor, SPINT2, restricts cleavage-activation efficiently for a range of influenza viruses and for human metapneumovirus (HMPV). SPINT2 treatment...

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Literature Corpus work: ce6a6880-bfc5-534e-b9eb-c639ccda2c68
DOI: 10.1101/752592

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