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Article

Influenza HA subtypes demonstrate divergent phenotypes for cleavage activation and pH of fusion: implications for host range and adaptation.

PLoS pathogens - 1 Feb 2013

Galloway Summer E, Reed Mark L, Russell Charles J, Steinhauer David A

Abstract excerpt

The influenza A virus (IAV) HA protein must be activated by host cells proteases in order to prime the molecule for fusion. Consequently, the availability of activating proteases and the susceptibility of HA to protease activity represents key factors in facilitating virus infection. As such, understanding the intricacies of HA cleavage by various proteases is necessary to derive insights into the emergence of...

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Share to Hemagglutinin Glycoproteins, Influenza Virus
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Influenza A virus

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Source

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Identifiers

PMID: 23459660
DOI: 10.1371/journal.ppat.1003151
PMCID: PMC3573126

Genes

TMPRSS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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