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The Host Protease TMPRSS2 Plays a Major Role in <i>In Vivo</i> Replication of Emerging H7N9 and Seasonal Influenza Viruses

6 Mar 2014

Abstract excerpt

UNLABELLED: Proteolytic cleavage of the hemagglutinin (HA) protein is essential for influenza A virus (IAV) to acquire infectivity. This process is mediated by a host cell protease(s) in vivo. The type II transmembrane serine protease TMPRSS2 is expressed in the respiratory tract and is capable of activating a variety of respiratory viruses, including low-pathogenic (LP) IAVs possessing a single arginine residue...

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PMID: 24600012
DOI: 10.1128/jvi.03677-13

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