Article

Efficacy of Host Cell Serine Protease Inhibitor MM3122 against SARS-CoV-2 for Treatment and Prevention of COVID-19

2024-02-12

Abstract excerpt

<h4>ABSTRACT</h4> We have developed a novel class of peptidomimetic inhibitors targeting several host cell human serine proteases including transmembrane protease serine 2 (TMPRSS2), matriptase and hepsin. TMPRSS2 is a membrane associated protease which is highly expressed in the upper and lower respiratory tract and is utilized by SARS-CoV-2 and other viruses to proteolytically process their glycoproteins, enabl...

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Literature Corpus work: 42ac2b96-8723-5250-aa95-bc1edbb440b5
DOI: 10.1101/2024.02.09.579701

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