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Article

Role of host cellular proteases in the pathogenesis of influenza and influenza-induced multiple organ failure

25 Jul 2011

Abstract excerpt

Influenza A virus (IAV) is one of the most common infectious pathogens in humans. Since the IVA genome does not have the processing protease for the viral hemagglutinin (HA) envelope glycoprotein precursors, entry of this virus into cells and infectious organ tropism of IAV are primarily determined by host cellular trypsin-type HA processing proteases. Several secretion-type HA processing proteases for seasonal...

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PMID: 21801859
DOI: 10.1016/j.bbapap.2011.07.001

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